The goal of the course is to teach the course participants both theory and application of methods for linkage analysis (parametric and nonparametric).

Emphasis in this course is on strategies for genetic mapping of human Mendelian and complex traits. It will include theory as well as practical exercises. The exercises will be carried out using a variety of computer programs (LINKAGE, GENEHUNTER, MERLIN, ALLEGRO, SIMWALK2, SLINK and SUPERLINK, etc.) and with pencil and paper. TOPICS include: parametric methods (two-point and multipoint analysis); allele sharing (nonparametric) methods for sib-pairs and extended families (two-point and multipoint analysis); variance components analysis; homozygosity mapping; fine mapping; linkage admixture (heterogeneity); haplotype reconstruction; data quality control; sample size estimation (extended families [simulation studies] and sib-pairs) and estimating empirical p-values.

Costs: € 725 (researchers from an academic institution) resp. € 1.400 (individuals from private or profit companies)

Inexpensive housing is available for course participants at the MDC.

Maximum number of participants: 30

Application deadline: May 18^th, 2009

Organisers: Suzanne Leal (Baylor College of Medicine) and Michael Nothnagel (Kiel University & Max Delbrück Center).

Further information can be found at the meeting website

Please note that a Genetic Association Course will be held a the MDC in Berlin in November (read more).