EVOLution of TREEs as drivers
of terrestrial biodiversity

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Genome-wide association studies using mixed models
From Wednesday 05 September 2012
To Friday 07 September 2012
Contact Martin Lascoux (This email address is being protected from spambots. You need JavaScript enabled to view it.)


This course provided a general background for statistical models used in association studies with an emphasis on mixed model approaches. Multi-trait and multi-locus extensions of models of genotype-phenotype association were discussed with applications to data and hands-on examples. The course covered both genotype-phenotype associations and genotype-environment associations, and discussed parallels between these approaches. In addition, downstream analyses (e.g., gene set and functional class enrichment and experimental work) has been discussed that can be used to help validate association study results and to clarify the biological basis for the observed signals. Participants received practical experience running analyses with a sample data set using R packages.


1. Introduction to mixed models with application to genotype-phenotype association studies
2. Another application of mixed models: genotype-environment association studies.
3. More complex models such as multi-trait and multi-locus models.
4. Range-wide versus population-specific analyses - pros and cons of using geographically restricted versus range-wide sampling
5. Methods for validating the results and integrating results with other genome-wide information (e.g, enrichment of likely functional variants, relevant candidate gene sets, experimental follow-up) and making biological interpretations
6. Practical experience using R with a sample data set

Location Uppsala, Sweden

Funding Initiatives

Funding is available for EVOLTREE members: training expense reimbursement, conference grants and project grants


eLab Services

The eLab provides a search interface which can browse over all databases currently available within the EVOLTREE project.



Scientific events of interest to the EVOLTREE community are listed here. Conference grants are available to cover expenses



EVOLTREE is a growing resource, archived Articles can be found here.

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